Can I Give My Dog Prednisone And CBD Oil

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Prednisone for dogs – a standard solution used by veterinarians everywhere to prevent dogs from getting sick. Read to know more here. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. Have you ever been prescribed steroids for your pet? What if I told you there is a natural alternative? Full Spectrum Hemp CBD vs Steriods!

Prednisone for Dogs

No matter who you are, your dog quickly becomes a treasured member of the family, and like any family member, they will get sick at some point. And, just like any other member of the family, you will go above and beyond to help them get better. One treatment for this is prednisone, a standard solution used by veterinarians everywhere. However, is it all it’s cracked up to be, or is there a better way?

What is Prednisone?

Prednisone is a steroid used to treat inflammation in your dog while also assisting its immune system. It is stronger than the naturally released cortisol, and it is converted to prednisolone in your dog’s liver . If your dog has a weak liver function , vets may skip prednisone altogether, and instead prescribe prednisolone to save on conversion.

As it can treat a wide range of diseases and conditions, prednisone is a popular option for ensuring your dog gets back to its silly and energetic self. However, as with many treatments out there, it does come with side effects that you may want to avoid.

Why is Prednisone Bad for Dogs?

These side effects can range from increased thirst to lethargy, and while these may not be considered too extreme, they can still have adverse effects on your dog’s health . This is especially true when side effects compounds. For example, increased thirst can lead to more frequent urination, but as another side effect of prednisone is infrequent urination in dogs, it could cause an infection .

Other side effects include increased appetite , which can cause discomfort, and it can also take longer for wounds to hea l, which is especially concerning if your dog gets sick or injured easily during his or her routine walk.

Furthermore, vomiting and diarrhea are other possible side effects, and this can happen even if your dog does not overeat during mealtime.

There is also a chance that it could affect their overall behavior, becoming more aggressive. After all, no one wants their dog to snap, bark, or growl at guests, strangers, or even their family members, and if you have other pets and small children, this could be a cause for concern.

There are also long-term risks associated with prednisone prescriptions and treatment, primarily if you use the steroid for an extended time. Conditions such as Addison’s disease, Cushing’s disease, diabetes, heart problems, or even heart attacks are potentially fatal issues, so it’s worth understanding alternatives to using prednisone to treat your dog’s health problems.

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Why Should You Use CBD Instead?

Using CBD for treatment is a superb and all-natural alternative to pharmaceutical medications. These solutions, which you can find on the Dop Dog store, can get your dog back to perfect health just as quickly, and without the same issues that you might encounter with prednisone.

Pros

It’s non-toxic

As an all-natural ingredient, you can trust that CBD treatment is entirely non-toxic . This helps reduce the risk of side-effects and will focus only on treating whatever issues your dog may suffer from.

It’s more affordable.

If you thought medicine was expensive for humans, medicine for dogs, or any pet, is on a whole other level. As a dog owner, you know you will do anything it takes to ensure your dog gets back to its usual self, so you are willing to spend whatever you need to make sure that happens.

CBD treatments are more affordable than other medical treatments , which is excellent news for anyone on a budget or looking for a natural and affordable solution. Plus, with the extra money you save on medicine, you can start planning your next doggy-and-you vacation. We hear the Rockies is terrific this time of year.

It treats many common problems.

From cancer pain to anxiety, CBD can treat a range of issues your dog might encounter. As it is all-natural, there is no need to worry about extreme side effects. It can also fight off potential cancer cells, reduce aggressive behavior, ease anxiety , and help with arthritis. This ensures that your dog will bound around the park for many, many years to come.

Your dog won’t get high off it.

There is zero THC , the psychoactive component of cannabis; you don’t need to worry about your dog getting high and eating all of the snacks in the cupboard.

Cons

While CBD can be useful for treating your dog for a range of problems, illnesses, and diseases, it is not entirely perfect . As with anything you allow your dog to ingest, you must understand the cons as well as the pros.

It can still make them lethargic.

As your dog will not be used to CBD as medication, there is a chance that it may become less energetic when you start using it . Because of this, it’s worth starting the treatment in small doses to get them used to the effects.

You can still encounter problems if you give them too much.

Likewise, giving your dog too much CBD treatment can have effects on your pooch. You must follow the application guidelines to prevent this from happening.

Even with these cons, there are still more pros for using CBD as a treatment for your dog . With this in mind, it’s worth considering your options the next time your dog appears to be suffering from anxiety or more significant problems to see whether CBD is the solution.

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Doggy Treats

If your dog is sick or ill and you want an all-natural remedy to get them back on their feet, so you can start going on adventures again, then take the time to consider a CBD rather than prednisone. For all your doggy’s CBD needs, don’t forget to check out the Dope Dog store , as well as embrace the wealth of detailed information on this blog!

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Can my Dog take CBD Oil While Taking Other Medications?

With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.

In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.

Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.

Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.

CBD can alter the way your dog processes certain medications

Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.

CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.

There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.

You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.

Benefits of CBD Oil for Dogs

Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.

A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)

The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.

FDA & CBD

The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.

Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.

Blood Pressure and CBD Oil

High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.

A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:

The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”

CBD Oil Interacts with Anti-Seizure Meds

A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.

Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.

Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.

Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.

Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”

The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “

A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”

Cytochrome P450

CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.

When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.

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Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.

NSAIDs and Corticosteroids

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.

That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.

Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.

NSAID’S include the following:

  • Rimadyl
  • Metacam,
  • Deramaxx,
  • Etogesic

Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.

Common corticosteroids include the following:

  • Prednisone
  • Triamcinolone,
  • Dexamethasone,

The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?

CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.

Steroids vs. CBD: A Topic of Truths and Transitions

Chances are that most humans and pets have been prescribed a steroid medication at some point in their life for treatment of one or more medical conditions. Whether it be for inflammation, allergies, or another type of illness, injectable and oral steroids have been applied by doctors and veterinarians for decades as a part of treatment plans due to their effectiveness in addressing numerous symptoms quickly and effectively. However, although the relatively fast effects felt by starting a steroid may be impressive, long-term use can and very often lead to serious side effects, both in humans and pets. Moreover, despite newer age doctors trying to move away from heavy use and dependence on steroids, this class of medications is still to this day used more than it should be, given that we know now what they likely lead to over time.

In comparison, CBD and other cannabis-based therapies have recently been found to effectively address a majority of the same symptoms steroids remediate, but do not tend to cause any of the same adverse long-term side effects steroids come with. Therefore, there is a huge potential promise in considering CBD as a legitimate therapeutic substitution for steroids when developing a safe and effective therapeutic treatment plan. Ultimately, when a life of longevity, health, and happiness is the long-term goal, understanding the ramifications and alternatives to steroid therapy is critical for the well-being of patients, including your pet.

Table of Contents

What are Steriods?

The term “steroid” simply describes a class of molecules that have a variety of influences and effects within an animal’s body. Specifically, there are “natural steroids” which our bodies make on their own, and “synthetic steroids” that are produced in laboratories that overlap with our internal bodily systems.

Steroids became widely popular in the 1940’s for inflammatory conditions . Corticosteroids in particular were and continue to be used to treat symptoms associated with arthritis and other degenerative musculoskeletal conditions. In fact, in 1950, the Nobel Prize for Physiology or Medicine went to Dr. Philip Hench, Edward Calvin Kendall, and Tadeus Reichstein for the discovery of cortisone and its applicable uses with rheumatoid arthritis.

Since their discovery and explosion onto the medical scene, steroids eventually became widely over-prescribed, as they were viewed as the “miracle drug” that could help with any and all conditions in conjunction with those initially known. However, as the repercussions of long-term use then began to surface as well, a shift towards healthier, long-term substitutions has slowly begun. Many doctors and veterinarians now only prescribe steroids for short-term applications and rely on multimodal therapies to promote long-term control of the underlying illness(es). However, many other medical professionals have not yet adopted this pattern, and still use steroids more often than is thought to be safe or required. T here are a small number of situations where steroids must be used for long-term immunosuppression (including some refractory autoimmune diseases and Addison’s Disease), but again, these are rather uncommon. Unless your pet has one of these conditions, steroids should be considered a short-term solution only.

The most common steroids prescribed by most veterinarians are prednisone, prednisolone, hydrocortisone topicals, and TEMARIL-P . Steroids do, in fact, reduce inflammation in the body, but not without a cost. The most common side effects of early steroid use include polyuria (excessive urination), polydipsia (excessive thirst), polyphagia (excessive signs of hunger despite not actually requiring more food), and panting. Steroids are also well-known for their serious, and sometimes dangerous, side effects including:

  • Weight gain
  • Salt and fluid retention
  • Diabetes
  • Cardiac Problems (Heart)
  • Increased secondary infection risk
  • Slower wound healing
  • Loss of muscle mass
  • Hepatic Problems (Liver)

If any of the following serious side effects occur, stop giving Temaril-P and seek emergency veterinary medical attention ; an allergic reaction ( difficulty breathing; swelling of the lips, tongue or face; hives ). Trimeprazine can cause drowsiness, tremors and muscle weakness . Prednisolone may cause symptoms of Cushing’s disease which include increased thirst, urination and hunger as well as vomiting and diarrhea . Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet. Do not give any other over the counter or prescription medications, including herbal products, during treatment with Temaril-P without first talking to the veterinarian. Many other medications can interact with Temaril-P resulting in side effects or altered effectiveness. These include sedatives, anesthetics, pain medications, epinephrine and procaine.”

As stated above, there are few cases where lifetime use of steroids is necessary. But, in the majority of cases where it is not a necessity, the body will become susceptible to developing one or more of the many side effects listed, and will also be subject to dependency and severe withdrawal effects if steroid therapies are discontinued too quickly. That’s why doctors generally advise a gradual tapering protocol off of steroids toward the end of a long-term treatment plan. Ultimately, if a steroid has been used for more than 7 days, then it is not advisable to stop this medication abruptly without the supervision of a medical professional, as this can prove detrimental to your pet’s health as well.

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What are Steriods Used for?

Oral steroids are the most commonly prescribed medication for dogs (and us). These medications again are synthetic steroids, meaning they are not naturally produced by our body . They are most often prescribed to treat inflammatory conditions, skin conditions, non-infectious respiratory diseases, and degenerative neuromusculoskeletal conditions.

According to Dr. Gary Richter , “ steroids are some of the most powerful anti-inflammatory medications available .” Because of this, they tend to be a commonplace treatment for pets with skin and respiratory conditions. Dr. Richter continued to state, “ despite steroids’ ability to reduce inflammation, their long term side effects far outweigh their benefits .”

Steroid-Sparing Methods

CBD is being researched as a ‘steroid-sparing option.’ A study published in Current Neuropharmacology indicated CBD has therapeutic benefits for both people and pets who suffer from chronic pain. There is an abundance of compounds found to reduce inflammation in both us and our pets. The most common phytocannabinoids found in the Cannabis plant, THC and CBD, both possess anti-inflammatory properties. Other minor cannabinoids, including CBG, CBC, and THCV were also found to provide anti-inflammatory properties as well.

According to Future Medicinal Chemistry , “ cannabinoids have exhibited significant potential to be used as novel anti-inflammatory agents and specific targeting of CB2 receptors holds the promise of mediating immunosuppressive effects without exerting psychotropic side effects.”

A Baylor College of Medicine study, using In vitro and in mouse models, found that CBD significantly attenuated the production of proinflammatory cytokines IL-6 and TNF-α while elevating levels of anti-inflammatory IL-10. In the veterinary study, CBD significantly decreased pain and increased mobility in a dose-dependent fashion among animals with an affirmative diagnosis of OA.

According to a veterinarian named Steven Katz , who is one of only a few doctors applying CBD-based therapies in practice, “our experience in my clinic has shown cannabidiol (CBD) is an effective treatment in reducing inflammatory response . We have a passion for improving dogs’ quality of life, and we look forward to learning all we can about therapeutic methods to achieve this.”

The Ultimate Question: Steriods vs. CBD

First things first: If you are reading this and your dog is already taking steroids, it’s absolutely critical the regimen is not stopped immediately. Never attempt to taper this medication without the supervision of a licensed veterinarian.

Taking a full-spectrum CBD-based product in combination with a steroid, like prednisone, will most likely (not guaranteed) not result in any detrimental adverse effects. Although both compounds are broken down by the liver, taking both at the same time is unlikely to cause “liver overload” unless the liver is already unhealthy (which would have been or can only be determined by submitting bloodwork with your veterinarian). If the liver is already “sick” then there may be hypothetical concerns regarding administering both at the same time, even though research up to this point has not proven such statements. The reason for this is because research indicates that CBD and other cannabis-based molecules are broken down by the “cytochrome p450 enzyme” group located in the liver, and that CBD specifically inhibits a component of the activity of a particular enzyme (CYP3A4) which is used by the body to break down numerous other molecules. The effects of this are still not entirely known, but with an unhealthy liver, it is highly advised to be more careful when considering any extra stress it may cause on this organ. We do know that Prednisone does cause liver “induction” resulting in numerous secondary effects, both on the liver’s functioning ability and its ability to handle other molecules simultaneously, such as CBD and the other active compounds in a full-spectrum product. Again though, each animal is an individual, and therefore, each case must be addressed individually before making any decisions or conclusions.

Of course, given what we know about steroids and CBD, we should all desire to get more pets off of long-term steroid use, and if appropriate, use a properly-vetted Full Spectrum Hemp CBD-based therapy to address the conditions steroids were originally applied for. But, this transition must be done responsibly. The overall goal is and should always be to promote a lifestyle of optimum healthiness and happiness. With the proper diet, natural supplements, and safe remedies in times of illness like a properly vetted full-spectrum CBD-based product, there is an opportunity to enhance and maintain your pet’s overall well-being without abusing and over-using pharmaceuticals, in an age where pharmaceuticals still seem to be king.

Dr. Zac Pilossoph

Dr. Zac Pilossoph, a Long Island, NY born, nationally recognized veterinary medical professional, a top graduate of Tufts University Veterinary School of Medicine with post-graduate focused training in E/CC and Neurology/Neurosurgery at two of the most recognized programs in the country, and a young multidimensional serial entrepreneur, has rapidly and collaboratively helped promote a new wave of global evolution and individual empowerment in more ways than one. In addition to developing and launching several novel platforms in the veterinary and mental health fields, he is now quickly joining some of the most reputable leaders in the cannabis education and innovation space. Dr. Pilossoph is determined to synergize with colleagues, allowing evidence-based information to fuel a rapidly expanding industry. As one of the world’s most proactive cannabis-focused experts in his respective industry, Dr. Pilossoph provides tremendous value by delivering non-bias, harm reduction education, via both large-scale speaking engagements and individualized consultations, to the global cannabis pet and vet industry. Further, he is a Certified CBD Professional Educator through the CBD Training Academy and has started a nationally influential multi-tiered cannabis brokerage firm titled Excelsior Honour Associates. Lastly, he acts as a consultant for the CBD product space in order to impart as much quality, control, and consistency across the industry as much as possible. Ultimately, through candid education, fierce collaboration, and constructive evolution, Dr. Pilossoph is reversing stigmas and advancing the safe and effective consideration of cannabis into society, for all creatures on Earth.

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